The Meb Faber Show
The Meb Faber Show
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Meb Faber
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The Biotech Rebuild: Finding Alpha After the Drawdown with Chris Clark | #606

Nov 11, 2025 • 107 mins

Today’s guest is Chris Clark. Chris was a biotech PM for 10 years at RS Investments, managing $4.5 billion. In today’s episode, Chris discusses the complexities of the biotech sector, which has suffered a dramatic drawdown the past few years. He begins by explaining how biotech works, why it’s such a unique sector, and what has kept investors and companies frozen the past few years. He also explains the different perspectives of venture capitalists and public market investors, the current regulatory environment and how AI may reshape drug development.

Key Points

  • China's emergence as a significant player in biotech innovation is creating new opportunities for in-licensing products developed there, with regulatory acceptance of research conducted in China increasing.
  • The key to successful biotech investing lies in understanding the unique risk-reward dynamics of the sector, including the importance of having sufficient cash runway to navigate the capital-intensive and lengthy drug development process.
  • The biotech sector is currently presenting a generational buying opportunity, driven by historically low valuations and the potential for significant returns as the market begins to recover and M&A activity resumes.
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